Thomas A. Neubert

This study shows that the MAPT P301L mutation causes neuronal network hyperexcitability through subtype-specific tau pathology and altered synaptic transmission.

This study evaluates five anti-α-synuclein single-domain antibodies in Drosophila models, identifying 2H1 as the most effective in reducing pathology and improving disease parameters.

This study identifies VLK as an extracellular kinase that mediates EphB2 phosphorylation and pain responses by regulating synaptic protein interactions.

This study identifies that phosphorylated APP βCTF inhibits v-ATPase in Down Syndrome and Alzheimer's models, leading to lysosomal dysfunction.

This study shows that cardiolipin is essential for postnatal cardiac maturation by enabling mitochondrial cristae to accumulate OXPHOS proteins and protect them from degradation.

The paper investigates early molecular changes in the APP/PS1 mouse model of Alzheimer's disease, finding dysregulation of the de novo proteome in synaptic, lysosomal, and mitochondrial pathways before pathology develops.