David Schoppik

This study shows that the MAPT P301L mutation causes neuronal network hyperexcitability through subtype-specific tau pathology and altered synaptic transmission.

The paper identifies sim1a as a candidate gene for strabismus using transcriptomic analysis and CRISPR/Cas9 mutagenesis in zebrafish.

The paper shows that birthdate aligns vestibular sensory neurons with central and motor partners in a gaze stabilization circuit through a spatiotemporal 'first-come, first-served' mechanism.

This paper introduces CaBLAM, a bioluminescent Ca2+ indicator with improved dynamic range and Ca2+ affinity, enabling high-resolution imaging of cellular activity in cultured neurons and in vivo.

This study identifies distinct locomotor strategies in larval zebrafish under light and dark conditions, showing how light and circadian cues influence balance and navigation.

This study shows that oligodendrocytes support the functional development of subcortical premotor neurons and vertical navigation in larval zebrafish, but not the vestibulo-ocular reflex.

This study shows larval zebrafish adjust their swimming and posture strategies based on light conditions after losing lateral line hair cells, demonstrating multisensory control of elevation.

This study uses chemogenetic tools to investigate the role of Purkinje cells in postural control of larval zebrafish, showing their impact on pitch-axis posture and fin-body coordination.

The paper shows that sensory experience is not required for the maturation of the vestibulo-ocular reflex in larval zebrafish, as neuromuscular junction development drives reflex maturation.

The paper shows that tau load in specific brainstem neurons predicts balance deficits before cell death in zebrafish.

The paper shows that later ablation of vestibulospinal neurons in larval zebrafish causes greater postural instability, indicating their role in developmental balance refinement.

This study identifies a brainstem circuit in larval zebrafish that converts gravitational signals into vertical navigation by maintaining consistent heading.

The paper shows motor neurons are not required for proper connectivity in the vestibular reflex circuit for gaze stabilization.

The paper identifies Tre1 and S1pr1 as evolutionarily conserved regulators of astrocyte morphology through lipid signaling and competition for growth-promoting phospholipids.

The paper identifies molecular signatures and transcription factors that determine functional subtypes of motor neurons in zebrafish, showing their role in fast MN development.

The paper investigates synaptic inputs to vestibulospinal neurons in larval zebrafish, finding excitatory and inhibitory inputs shaped by utricular otoliths.

The paper reveals topographic organization in a zebrafish vestibular brainstem circuit by showing birthdate correlates with neuronal position, innervation patterns, and connectivity.

The paper introduces SAMPL, a high-throughput system for measuring posture and locomotion in small animals, demonstrating its use in zebrafish and showing genetic and developmental effects on movement.

The paper introduces Tilt In Place Microscopy (TIPM) to study neural responses to body rotations in larval zebrafish, showing reliable activity changes in vestibulospinal neurons during and after roll tilts.

This study investigates how vestibulospinal neurons in larval zebrafish encode body tilt and contribute to movement timing, coordination, and posture stability.

This study shows that zebrafish develop coordinated climbing by optimizing fin-body coordination, linking balance to the maturation of locomotion.

This study shows that zebrafish dscaml1 is crucial for retinal patterning and oculomotor circuit function, with mutations causing deficits in gaze stabilization and saccade fatigue similar to human ocular motor apraxia.

This study identifies how Drosophila central neurons decode wind direction by comparing signals from both antennae.

The paper identifies asymmetric projections of central vestibular neurons in zebrafish and shows how these projections enhance sensory encoding of nose-up stimuli while maintaining gaze stabilization.

This study shows larval zebrafish use independent volitional and reflexive movements for locomotion, revealing a simple control scheme that enables effective but inflexible swimming.

This study shows that ocular motoneuron pools in zebrafish develop along a dorsoventral axis, with dorsal neurons born before ventral ones, influencing their identity and function.