Soomin C. Song

Loss of SUR1 and Kir6.2 ATP-sensitive potassium channel subunits produces comparable neuronal excitability and morphine antinociception

This study shows that loss of either SUR1 or Kir6.2 subunits in neurons increases dorsal root ganglion excitability and reduces morphine antinociception in mice.

Pathological tau leads to network hyperexcitability through neuronal-subtype-specific functional impairment

This study shows that the MAPT P301L mutation causes neuronal network hyperexcitability through subtype-specific tau pathology and altered synaptic transmission.

Purinergic signaling promotes gliomagenesis through nuclear calcium transients

This study identifies purinergic signaling via P2RY1 receptors and nuclear calcium transients as a driver of glioblastoma tumorigenesis, with therapeutic potential through P2RY1 inhibition.

Kir6.1, a component of an ATP-sensitive potassium channel, regulates natural killer cell development

This study identifies Kir6.1 as a key regulator of natural killer cell development in mice, showing its expression in mature NK cells and its role in NK-cell differentiation.

Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy

This study investigates neuronal function and network activity in early-stage tauopathy mice, finding hypofunction in motor cortical neurons and partial restoration with tau antibody treatment.

Vagus nerve stimulation recruits the central cholinergic system to enhance perceptual learning

This study shows that vagus nerve stimulation enhances perceptual learning in mice by activating the central cholinergic system during auditory tasks.

Astrocytic TDP-43 dysregulation impairs memory by modulating antiviral pathways and interferon-inducible chemokines

This study shows that TDP-43 accumulation in astrocytes impairs memory by altering antiviral pathways and chemokine signaling between astrocytes and neurons.

Input-Specific Inhibitory Plasticity Improves Decision Accuracy Under Noise

The paper investigates inhibitory plasticity in mouse auditory cortex, finding that SST+ interneuron inputs show the most potentiation and contribute to decision accuracy under noise.

Innate sensitivity and plastic mechanisms in auditory cortex for reliable maternal behavior

The paper shows that maternal behavior in mice arises from innate auditory cortex sensitivity combined with experience-dependent plasticity, enabling reliable pup retrieval.