Changyi Ji

Pathological tau leads to network hyperexcitability through neuronal-subtype-specific functional impairment

This study shows that the MAPT P301L mutation causes neuronal network hyperexcitability through subtype-specific tau pathology and altered synaptic transmission.

Cell-Type-Selective Cortical Pathology and Functional Deficits in Synucleinopathy

This study investigates cell-type-specific effects of synucleinopathy in the motor cortex, showing excitatory neuron vulnerability and disrupted network function leading to motor deficits.

Single-Domain Antibody-Based Autophagosome-Targeting Chimera for Tau Clearance and Motor Function Restoration in Tauopathies

This paper presents a single-domain antibody-based protein degrader that reduces tau levels and improves motor function in tauopathy models.

Neuronal hypofunction and network dysfunction in a mouse model at an early stage of tauopathy

This study investigates neuronal function and network activity in early-stage tauopathy mice, finding hypofunction in motor cortical neurons and partial restoration with tau antibody treatment.

Single-Domain Antibody-Based Protein Degrader for Synucleinopathies

This paper develops a single-domain antibody-based protein degrader that enhances proteasomal and lysosomal degradation of α-synuclein in synucleinopathy models.

BAG3 regulation of Rab35 mediates the Endosomal Sorting Complexes Required for Transport /endolysosome pathway and tau clearance

This study identifies a BAG3-TBC1D10B-Rab35 regulatory axis that modulates ESCRT-dependent tau clearance and links its dysfunction to Alzheimer's disease pathogenesis.

BAG3 and SYNPO (synaptopodin) facilitate phospho-MAPT/Tau degradation via autophagy in neuronal processes

This study shows BAG3 and SYNPO promote autophagy-mediated degradation of phosphorylated MAPT in neuronal synapses, preventing its accumulation and maintaining synaptic health.