DIMT1, a regulator of ribosomal biogenesis, controls beta-cell protein synthesis, mitochondrial function and insulin secretion
Gaurav Verma, Alexander Bowen, Sevda Gheibi, Alexander Hamilton, Sowndarya Muthukumar, Luis Rodrigo Cataldo, Olof Asplund, Jonathan L.S. Esguerra, Alexandros Karagiannopoulos, Claire Lyons, Elaine Cowan, Cristian Bellodi, Rashmi B. Prasad, Malin Fex, Hindrik Mulder
This study identifies DIMT1 as a regulator of ribosomal biogenesis in beta-cells, showing its role in mitochondrial function and insulin secretion, with implications for type 2 diabetes.
Journal of Biological Chemistry · Feb 8, 2022Peer-reviewedMolecular Biology