Rashmi B. Prasad

The paper conducts a multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycemic traits, identifying novel loci and highlighting limited pregnancy-specific genetic effects.

This study identifies HOXB6 and HOXB8 as regulators of immune-cancer cell interactions in pancreatic cancer, showing their role in promoting tumorigenesis and treatment resistance.

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

The paper conducts an epigenome-wide association study of serum folate in maternal blood, identifying three CpG sites associated with folate levels and some cardiometabolic traits.

This study shows that TYK2 is critical for β-cell development by regulating KRAS and IFN responses, suggesting TYK2 inhibition as a therapeutic target for type 1 diabetes.

The paper identifies splicing QTLs in human pancreatic islets that contribute to type 2 diabetes susceptibility by affecting gene splicing and revealing novel molecular mechanisms.

The paper introduces Islet Gene View (IGW), a platform that integrates gene expression and phenotypic data from pancreatic islets to explore T2D-related gene expression changes and their functional implications.

This study identifies DIMT1 as a regulator of ribosomal biogenesis in beta-cells, showing its role in mitochondrial function and insulin secretion, with implications for type 2 diabetes.

This study examines heritability and parent-of-origin effects on cardio-metabolic traits in a birth cohort, finding age-related shifts in parental influences.

EPIPREG collects DNA methylation data from pregnant women in Norway to study associations with cardiometabolic traits and ethnic disparities in health.

The paper analyzes the robustness of multilayer biological networks by integrating gene regulatory, protein-protein interaction, and metabolic data to assess how perturbations affect system stability.

The paper investigates how genetic variants affect gene expression in human pancreatic islets and identifies candidate genes linked to type 2 diabetes.

The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.

The paper detects systematic errors in large genomic datasets by analyzing batch effects, finding coding regions have more errors than non-coding regions.

The paper identifies NFATC4 as a key regulator of Type 2 Diabetes genes by analyzing a gene regulatory network in pancreatic islets and linking it to eQTLs and differential expression.

This study uses haplotype sharing among Finns to reconstruct recent population history and identify regions with increased rare disease variant sharing.