Author

Olof Asplund

Lund UniversityORCID 0000-0001-8449-8907Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Research Focus:gene regulatory network inference· 3 Assay:DNA methylation· 2 Approach:experimental assay· 2 Assay:proteomics· 2

Frequent Co-Authors

Ola HanssoniD· 3 shared Rashmi B. PrasadiD· 3 shared Adam Philip SharplesiD· 2 shared Aino HeikkineniD· 2 shared Gad HatemiD· 2 shared Hindrik MulderiD· 2 shared Kirsi Hannele PietiläineniD· 2 shared Larisa Margaret HauptiD· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersMolecular Biology

Ola HanssonORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Molecular Landscape of Modality-Specific Exercise Adaptation in Human Skeletal Muscle through Large-Scale Multi-OMICs Integration

Macsue Jacques, Shanie Landen, Adam Philip Sharples, ANDREW P. GARNHAM, Ralf B. Schittenhelm, Joel Stele, Aino Heikkinen, Elina Sillanpää, Miina Ollikainen, James R. Broatch, Navabeh Zarekookandeh, Ola Hanson, Ola Ekström, Olof Asplund, Séverine Lamon, , Nir Eynon

This study integrates multi-OMIC data from 12 cohorts to identify exercise-specific molecular signatures and gene regulatory patterns in human skeletal muscle.

bioRxiv · Jul 14, 2024 · PreprintMolecular Biology

Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

Sarah Amandine Caroline Voisin, Kirsten Seale, Macsue Jacques, Shanie Landen, Nicholas R. Harvey, Larisa Margaret Haupt, Lyn Robyn Griffiths, Kevin J. Ashton, Vernon G. Coffey, Jamie‐Lee M. Thompson, Thomas M. Doering, Maléne E. Lindholm, Colum P. Walsh, Gareth W. Davison, Rachelle E Irwin, , Nir Eynon

This study shows exercise training reduces epigenetic and transcriptomic aging in human skeletal muscle, while muscle disuse accelerates transcriptomic aging.

Aging Cell · May 2, 2023Peer-reviewedMolecular Biology

Islet Gene View - a tool to facilitate islet research

Olof Asplund, Petter Storm, Vikash Chandra, Gad Hatem, Emilia Ottosson-Laakso, Dina Mansour Aly, Ulrika Krus, Hazem Ibrahim, Emma Ahlqvist, Tiinamaija Tuomi, Erik Renström, Olle Korsgren, Nils Wierup, Mark R. Ibberson, Michele Solimena, , Rashmi B. Prasad

The paper introduces Islet Gene View (IGW), a platform that integrates gene expression and phenotypic data from pancreatic islets to explore T2D-related gene expression changes and their functional implications.

Life Science Alliance · Aug 10, 2022Peer-reviewedMolecular Biology

DIMT1, a regulator of ribosomal biogenesis, controls beta-cell protein synthesis, mitochondrial function and insulin secretion

Gaurav Verma, Alexander Bowen, Sevda Gheibi, Alexander Hamilton, Sowndarya Muthukumar, Luis Rodrigo Cataldo, Olof Asplund, Jonathan L.S. Esguerra, Alexandros Karagiannopoulos, Claire Lyons, Elaine Cowan, Cristian Bellodi, Rashmi B. Prasad, Malin Fex, Hindrik Mulder

This study identifies DIMT1 as a regulator of ribosomal biogenesis in beta-cells, showing its role in mitochondrial function and insulin secretion, with implications for type 2 diabetes.

Journal of Biological Chemistry · Feb 8, 2022Peer-reviewedMolecular Biology

Influence of genetic variants on gene expression in human pancreatic islets - implications for type 2 diabetes

Ana Viñuela, Arushi Varshney, Martijn van de Bunt, Rashmi B. Prasad, Olof Asplund, Amanda J. Bennett, Michael Boehnke, Andrew Anand Brown, Michael R. Erdos, João Fadista, Ola Hansson, Gad Hatem, Cédric Howald, Apoorva K. Iyengar, Toby Johnson, , Mark I. McCarthy

The paper investigates how genetic variants affect gene expression in human pancreatic islets and identifies candidate genes linked to type 2 diabetes.

Nature Communications · Sep 30, 2020Peer-reviewedGenomics