Decoding the Structural and Functional Impact of the Leukaemia-Associated A338V Mutation in GPR183
Louise Andersson, Patryk Adam Wesołowski, Laura Jahrstorfer, Alexander De Rosa, Tomas Heger, Vilmos Neuman, Adam K. Sieradzan, David J. Wales, Paweł Kozielewicz
This study examines how the A338V mutation in GPR183 affects receptor function, showing preserved G protein activation but impaired GRK2 and β-arrestin2 recruitment.
bioRxiv · Apr 1, 2026 · PreprintPharmacology & Toxicology