Paweł Kozielewicz

An AI-identified dual SMO/c-MET inhibitor overcomes stromal resistance and degrades c-MET to suppress pancreatic cancer.

The paper identifies a common evolutionary mechanism for class A GPCR activation using coevolution and machine learning, validated through molecular dynamics simulations and ligand effect modeling.

This study examines how the A338V mutation in GPR183 affects receptor function, showing preserved G protein activation but impaired GRK2 and β-arrestin2 recruitment.

The paper discovers a GPR183 inverse agonist using AI-driven virtual screening and a conformational biosensor, showing inhibition of Gi activation and β-arrestin2 recruitment.

The paper shows that mitochondrial proteins are locally synthesized at synapses and incorporated into respiratory chain complexes, supporting local mitochondrial biogenesis.