Systems-level properties of EGFR/Ras/ERK signalling amplify local signals to generate gene expressionplasticity
Alexander E. Davies, Taryn E. Gillies, Stefan Siebert, Michael Pargett, Savannah J. Tobin, Abhineet R. Ram, Celina Juliano, Gerald Quon, Mina J. Bissell, John G. Albeck
The paper shows that EGFR/Ras/ERK signaling in invasive breast cancer cells produces more dynamic and disordered ERK activity, leading to heterogeneous gene expression compared to non-malignant cells.
bioRxiv · Nov 9, 2018 · PreprintCancer Biology