Taryn E. Gillies

This paper introduces IMaP, a method to analyze tau proteoforms at the single-molecule level, revealing ordered phosphorylation patterns and disease-specific modifications.

The paper quantifies ERK activity in RAS-mutant cells and finds that mutant KRAS isoforms produce similar ERK output ranges despite differing biochemical activity, due to pathway-level rescaling mechanisms.

The paper shows that EGFR/Ras/ERK signaling in invasive breast cancer cells produces more dynamic and disordered ERK activity, leading to heterogeneous gene expression compared to non-malignant cells.