Alexander E. Davies

This study identifies FGFR-ERK signaling as a driver of adaptive resistance in osteosarcoma lung metastases and shows that combinatorial RTK inhibition enhances MCL1 inhibitor efficacy.

The paper introduces a compact, battery-powered organoid-on-chip system with programmable flow control, validated for culturing pancreatic cancer organoids and showing enhanced proliferation and drug response.

The paper introduces the SITE platform for live-cell ex vivo modeling of cancer and TME interactions, revealing tissue-specific dynamics and ERK signaling patterns in breast cancer.

This study uses the AID system with CRISPR/Cas9 to acutely degrade nucleolin in TNBC cells, revealing its role in cell cycle progression and division, and showing that its abrogation enhances the efficacy of mitotic inhibitors.

This study evaluates how CDK4/6 and AURKA inhibition enhances NK cell homing and tumor-killing in melanoma models using tumor-on-a-chip platforms.

This paper introduces a single-cell bioprinting method that reconstructs native cellular microenvironments with subcellular resolution, enabling precise interrogation of spatial interactions.

The paper introduces a new AID system that enables cell cycle-specific protein degradation, allowing study of protein roles in specific cell cycle phases.