Abhineet R. Ram

Influenza A defective viral genomes and non-infectious particles are in-creased by host PI3K inhibition via anti-cancer drug alpelisib

This study shows that alpelisib, a PI3K inhibitor, increases defective viral genomes and particles in A/H3N2 but decreases total particles in A/H1N1, suggesting host metabolism influences viral defectiveness.

Deciphering the History of ERK Activity from Fixed-Cell Immunofluorescence Measurements

The paper develops a framework to infer ERK signaling dynamics from fixed-cell immunostains by combining machine learning and differential equations, showing that protein levels reflect different activation timescales.

Systems-level properties of EGFR/Ras/ERK signalling amplify local signals to generate gene expressionplasticity

The paper shows that EGFR/Ras/ERK signaling in invasive breast cancer cells produces more dynamic and disordered ERK activity, leading to heterogeneous gene expression compared to non-malignant cells.