Polycomb repression works without Siesta
Tatyana G. Kahn, Andres Garrido, A. A. Yushkova, Maria Kim, Alexander Glotov, Sweda Sreekumar, Jan Larsson, Yuri B. Schwartz
The paper shows that variant RING1 complexes in Drosophila can ubiquitylate H2A without being part of the Polycomb repression system, and that H2A ubiquitylation has minimal impact on transcriptional repression.
bioRxiv · Jul 18, 2025 · PreprintGenetics