Tatyana G. Kahn

The paper establishes hybrid Drosophila cell lines to study genome instabilities and identifies incompatibility genes and chromosomal regions prone to loss in hybrids.

The paper shows that variant RING1 complexes in Drosophila can ubiquitylate H2A without being part of the Polycomb repression system, and that H2A ubiquitylation has minimal impact on transcriptional repression.

The paper identifies DNA elements that tether canonical PRC1 to human genes and shows differences in sequence features compared to PRC2 binding.

The paper identifies hundreds of Drosophila chromatin insulator elements dependent on Cp190 and CTCF by analyzing genomic contacts, transcriptomes, and protein binding in deficient cells.

This study identifies the domains of Ash1 required to counteract Polycomb repression in Drosophila, showing that the BAH, PHD, and SET domains are essential while AT hooks are not.

The paper identifies a PRC1 targeting element (PTE) and CpG-island that together form a Polycomb Response Element for the CCND2 oncogene, showing their role in coordinating PRC1 and PRC2 recruitment.