CFTR dysfunction in the intestinal epithelium is sufficient to promote pathogenic expansion of E. coli and enhanced barrier permeability in cystic fibrosis
Philip P. Ahern, Naseer Sangwan, Apollo Stacy, Jessica M. Snyder, Zaria Johnson, M. Cua, Brian Chang, Alexander Maynard, Lauren Smith, Filip Sagl, Brandon Bakos, Akeem Santos, Tina Nunn, Anne-Marie C. Overstreet, Michael J. Wannemuehler, , Adeline M. Hajjar
This study shows that CFTR dysfunction in intestinal epithelial cells promotes E. coli expansion and increased intestinal permeability in cystic fibrosis.
bioRxiv · Sep 19, 2026 · PreprintMicrobiology