Philip P. Ahern

This paper engineers Salmonella enterica to sense and deplete kynurenine in tumors, enhancing antitumor immune responses and efficacy in mouse models.

This study shows that CFTR dysfunction in intestinal epithelial cells promotes E. coli expansion and increased intestinal permeability in cystic fibrosis.

This study identifies strain-level antigen variation in Bacteroides thetaiotaomicron that enables immune evasion by CD4+ T cells, revealing a mechanism for strain discrimination in the microbiome.

This study identifies strain-specific molecular cues that regulate biofilm formation in Bacteroides thetaiotaomicron, revealing variation in responses to bile acids and acetic acid.