Redistribution of proteasomes through diffusion and cytoskeleton-dependent mechanisms upon stress induced by protein aggregates
Michael J. Morten, Yu Zhang, Bing Li, Jonathan X Meng, Kun Jiang, Liina Sirvio, Ji‐Eun Lee, Anna H. Lippert, Matilda Burridge, Katiuska Daniela Pulgar Prieto, Alexander R. Carr, Aleks Ponjavic, Steven F. Lee, Daniel J. Finley, David Klenerman, Yu Ye
The paper quantifies proteasome re-organization during proteotoxic stress using single-molecule microscopy and shows cytoskeleton-dependent movement restrictions.
bioRxiv · Jan 16, 2025 · PreprintBiophysics