Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma
Christina M. Fitzsimmons, Mariana D. Mandler, Judith C. Lunger, Dalen Chan, Siddhardha S. Maligireddy, Alexandra C Schmiechen, Supuni Thalalla Gamage, Courtney N. Link, Lisa M. Miller Jenkins, King C. Chan, Þorkell Andrésson, Daniel R. Crooks, Jordan L. Meier, William Marston Linehan, Pedro J. Batista
This study investigates how fumarate accumulation affects RNA methylation by targeting specific 2OGDD enzymes in HLRCC cell lines, revealing differential impacts on m6A, m1A, and f5C demethylases.
NAR Cancer · Jan 9, 2024Peer-reviewedMolecular Biology