Daniel R. Crooks

Band-selective IR PRESS for brain tumor spectroscopy allows robust detection of lactate

This paper introduces SPIR-PRESS, a magnetic resonance spectroscopy method that improves lactate detection in brain tumors by reducing lipid interference, showing increased sensitivity and broader metabolite profiling.

Low Field Magnetic Resonance Imaging to Detect Acute Kidney Injury

This study uses EPR oximetry to assess kidney oxygen levels in mice with kidney injury, showing increased pO2 post-injury and high-resolution spatial mapping of oxygen distribution.

Impaired oxidative phosphorylation drives primary tumor escape and metastasis

This study shows that impaired oxidative phosphorylation, driven by NDUFA4L2, promotes EMT and metastasis in renal cell carcinoma by altering chromatin accessibility.

Pharmacological Ascorbate Induces Transient Hypoxia Sensitizing Pancreatic Ductal Adenocarcinoma to a Hypoxia Activated Prodrug

This study shows that pharmacological ascorbate induces transient hypoxia in pancreatic ductal adenocarcinoma, enhancing the efficacy of the hypoxia-activated prodrug evofosfamide in some tumor models.

Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma

This study investigates how fumarate accumulation affects RNA methylation by targeting specific 2OGDD enzymes in HLRCC cell lines, revealing differential impacts on m6A, m1A, and f5C demethylases.