Christina M. Fitzsimmons

Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma

This study investigates how fumarate accumulation affects RNA methylation by targeting specific 2OGDD enzymes in HLRCC cell lines, revealing differential impacts on m6A, m1A, and f5C demethylases.

Extensible benchmarking of methods that identify and quantify polyadenylation sites from RNA-seq data

The paper benchmarks eight tools for identifying and quantifying alternative polyadenylation sites from RNA-seq data using real, synthetic, and 3'-end sequencing data.

Controlling CRISPR-Cas9 with ligand-activated and ligand-deactivated sgRNAs

Inserting theophylline aptamers into the sgRNA yields ligand-activated and ligand-deactivated guides that tune CRISPRi in E. coli over 11x to 13x dynamic ranges, enabling two-ligand multiplexing.