Jordan L. Meier

Molecular Basis for RNA Cytidine Acetylation by NAT10

This study determines the cryo-EM structure of NAT10 bound to a cytidine-CoA probe, revealing its mechanism for RNA N4-cytidine acetylation and its role in cellular processes.

Hierarchical small molecule inhibition of MYST acetyltransferases

This paper evaluates the potency and selectivity of MYST KAT inhibitors using chemoproteomic profiling and identifies new complex members, highlighting dose-dependent inhibition patterns and potential therapeutic applications.

A nuclear branched-chain amino acid catabolism pathway controls histone propionylation in pancreatic cancer

This study identifies a nuclear branched-chain amino acid catabolism pathway in pancreatic cancer that regulates histone propionylation and gene expression.

An in vivo screen identifies NAT10 as a master regulator of brain metastasis

This study identifies NAT10 as a master regulator of brain metastasis through an in vivo shRNA screen and shows its role in promoting tumor growth and metastasis via downstream effectors.

Transfer RNA acetylation regulates in vivo mammalian stress signaling

This study shows that tRNA acetylation regulates stress signaling in mammals by affecting ribosome function and interacting with the Gcn2 kinase.

A sequence-specific RNA acetylation catalyst

This study characterizes TkNat10, an RNA acetyltransferase from T. kodakarensis, showing its role in thermotolerance and its ability to modify RNA substrates with specific sequence preferences.

Inhibition of Ribosome Biogenesis in vivo Causes p53-Dependent Death and p53-Independent Dysfunction

This study investigates the effects of ribosome biogenesis inhibition in vivo by deleting Nat10 in mice, revealing p53-dependent and -independent consequences on acinar cell function and tumorigenesis.

Paralogue-selective degradation of the lysine acetyltransferase EP300

This study develops a small molecule, MC-1, that selectively degrades EP300 over CREBBP, revealing factors governing paralogue-specific degradation and its impact on cancer cell proliferation.

Rewiring of RNA methylation by the oncometabolite fumarate in renal cell carcinoma

This study investigates how fumarate accumulation affects RNA methylation by targeting specific 2OGDD enzymes in HLRCC cell lines, revealing differential impacts on m6A, m1A, and f5C demethylases.

Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution

The paper investigates the role of SNORD13 in rRNA acetylation across eukaryotes, showing its requirement in human and zebrafish but not in yeast or C. elegans.