William Marston Linehan

The paper shows TFE3 fusions upregulate CD44 and SPP1 in tRCC, with potential therapeutic implications.

The paper shows TEAD1 forms transcriptionally inactive condensates in cancer cell pericentromeric heterochromatin, acting as storage sites and influencing YAP/TEAD target gene expression.

This paper introduces SPIR-PRESS, a magnetic resonance spectroscopy method that improves lactate detection in brain tumors by reducing lipid interference, showing increased sensitivity and broader metabolite profiling.

This study creates a mouse model of SFPQ-TFE3-driven renal tumors and shows it induces lineage plasticity through mTORC1 activation.

This study shows that improving tumor blood flow enhances the abscopal effect in mice treated with radiation and PD-1 blockade, by increasing immune activation and reducing hypoxia.

This study uses EPR oximetry to assess kidney oxygen levels in mice with kidney injury, showing increased pO2 post-injury and high-resolution spatial mapping of oxygen distribution.

This study shows that impaired oxidative phosphorylation, driven by NDUFA4L2, promotes EMT and metastasis in renal cell carcinoma by altering chromatin accessibility.

This study shows that pharmacological ascorbate induces transient hypoxia in pancreatic ductal adenocarcinoma, enhancing the efficacy of the hypoxia-activated prodrug evofosfamide in some tumor models.

This study investigates how fumarate accumulation affects RNA methylation by targeting specific 2OGDD enzymes in HLRCC cell lines, revealing differential impacts on m6A, m1A, and f5C demethylases.