Author

Alexandra H. Christensen

University of Southern California

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Synthetic Biology· 1

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Approach:experimental assay· 1 Organism:yeast· 1

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Alessandro L V Coradini· 1 shared Cara B. HulliD· 1 shared Daniel T. LuskiD· 1 shared Ian M. EhrenreichiD· 1 shared Shawn YangiD· 1 shared

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Alessandro L V Coradini

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Recent·Most cited

Synthetic BiologyGeneticsPeer-reviewedOct 28, 2026

Synthetic collinearization of a chromosome segment enables genetic dissection of incompatibility between distant genera

Shawn Yang, Alexandra H. Christensen, Alessandro L V Coradini…·Ian M. Ehrenreich

This paper demonstrates that collinearization can overcome genetic incompatibility between distant yeast species by creating synthetic chromosome segments that substitute for native ones, revealing hundreds of genetic incompatibilities.

DOI 10.1093/genetics/iyag306

yeastexperimental assay

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