Ian M. Ehrenreich

A largely shared genetic architecture underlies Saccharomyces cerevisiae persistence across different mouse host genotypes

This study shows that Saccharomyces cerevisiae persistence in mice is polygenic with strong additive effects and minimal host-genotype interactions.

Synthetic collinearization of a chromosome segment enables genetic dissection of incompatibility between distant genera

This paper demonstrates that collinearization can overcome genetic incompatibility between distant yeast species by creating synthetic chromosome segments that substitute for native ones, revealing hundreds of genetic incompatibilities.

A novel reaction-diffusion architecture for engineering self-organized patterns in mammalian cells

This paper introduces a novel reaction-diffusion architecture called JAPI for engineering self-organized patterns in mammalian cells, demonstrating its ability to generate spatial patterns with fewer parameters than classical diffusion-based systems.

Global epistasis in budding yeast driven by many natural variants whose effects scale with fitness

The paper identifies 58 loci in budding yeast that interact with fitness, showing global epistasis where genetic perturbations have greater effects in more fit individuals.

Genome-scale analysis of interactions between genetic perturbations and natural variation

The paper identifies gene-perturbation interactions across genetic backgrounds in yeast using CRISPRi and combinatorial DNA barcode sequencing, revealing 460 genes with variable effects and 234 interacting loci.

Building synthetic chromosomes from natural DNA

This paper introduces CReATiNG, a method to build synthetic chromosomes from natural DNA in yeast, enabling chromosome recombination, modification, and deletion of non-adjacent regions.

Complex genetics cause and constrain fungal persistence in different parts of the mammalian body

The paper identifies genetic loci influencing fungal persistence in different mammalian organs using a yeast model, showing complex interactions between general and organ-specific alleles.

Genetic basis of a spontaneous mutation's expressivity

The paper identifies multiple genetic loci influencing the expressivity of a spontaneous mutation in budding yeast.

The interplay of additivity, dominance, and epistasis in a diploid yeast cross

The paper shows that in diploids, epistasis frequently modifies both additivity and dominance.

Multiple layers of cryptic genetic variation underlie a yeast complex trait

The paper identifies 21 loci underlying a yeast colony phenotype, showing cryptic genetic variation is revealed by specific perturbations and environmental contexts.

The stress-inducible peroxidase TSA2 enables Chromosome IV duplication to be conditionally beneficial in Saccharomyces cerevisiae

The paper identifies a chromosomal duplication in yeast that enhances tolerance to oxidative stress by duplicating the TSA2 gene.