Hua Bai

Design of solubly expressed miniaturized SMART MHCs

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

Mapping the evolution of computationally designed protein binders

This paper evolves computationally designed protein binders using in vivo hypermutation and maps their sequence-affinity landscapes to understand affinity improvements and mutation interactions.

Nucleation limited assembly and polarized growth of a de novo-designed allosterically modulatable protein filament

This paper designs a tunable protein filament that assembles in response to a peptide ligand and demonstrates its polarized growth and nucleation mechanisms.