A Conserved Landscape of Chemokine Receptor Co-expression Defines the Functional States of CD8+ T Cells in Melanoma
Rodney Macedo, David W Harle, Kevin Hoffer-Hawlik, Ximi Kevin Wang, Thomas McMahon-Skates, Alexandra Matschiner, Kirubel Belay, Yvonne M. Saenger, Benjamin Izar, Elham Azizi, Ran Reshef
The paper identifies co-expression patterns of chemokine receptors on CD8+ T cells that distinguish anti-tumor efficacy from off-target toxicity in melanoma.
bioRxiv · Dec 16, 2025 · PreprintImmunology