Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu
Charles K. Min, Jerome C. Nwachukwu, Yingwei Hou, Robin J. Russo, Alexandra Papa, Jian Min, Rouming Peng, Sung Hoon Kim, Yvonne Ziegler, Erumbi S. Rangarajan, Tina Izard, Benita S. Katzenellenbogen, John A. Katzenellenbogen, K. W. Nettles
This paper shows that estrogen receptor-α homodimers can function as conformational heterodimers, integrating different ligand signals to produce distinct agonist or antagonist activity profiles.
Proceedings of the National Academy of Sciences · Jun 3, 2024Peer-reviewedBiophysics