K.W. Nettles

This study shows that multi-region neurospheres from glioblastoma tumors retain spatial diversity and drug response patterns linked to their original biopsies, highlighting their importance for modeling intratumor heterogeneity.

The paper develops selective glucocorticoid receptor modulators (SGRMs) that modulate immune checkpoint function by altering GR activity states through structural design and machine learning.

This paper shows that estrogen receptor-α homodimers can function as conformational heterodimers, integrating different ligand signals to produce distinct agonist or antagonist activity profiles.