A PCNA-K164R mutation impinges on origin activation and mitotic DNA synthesis
Wendy Leung, Ryan M. Baxley, Emma L. Traband, Ya‐Chu Chang, Colette B. Rogers, Liangjun Wang, Wesley Durrett, Kendall Bromley, Lidia Fiedorowicz, Tanay Thakar, Anika Tella, Alexandra Sobeck, Eric A. Hendrickson, George‐Lucian Moldovan, Naoko Shima, Anja‐Katrin Bielinsky
This study shows that PCNA-K164 ubiquitination is essential for DNA gap filling during S/G2 phases and regulates mitotic DNA synthesis by influencing FANCD2 and MCM2-7 loading.
Cell Reports · Dec 1, 2023Peer-reviewedMolecular Biology