Author

Wendy Leung

University of Minnesota

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Anja‐Katrin BielinskyiD· 4 shared Colette B. RogersiD· 3 shared Eric A. HendricksoniD· 3 shared Liangjun WangiD· 3 shared Ryan M. BaxleyiD· 3 shared George‐Lucian MoldovaniD· 2 shared Tanay ThakariD· 2 shared Adam J. Harvey· 1 shared

Activity by Year

2020-2024 · peak 1/yr

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10 top collaborators · 39 mutual co-author links

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4 shared papersMolecular Biology

Anja‐Katrin BielinskyORCID

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4 papers

Recent·Most cited

Cell type specific suppression of hyper-recombination by human RAD18 is linked to PCNA K164 ubiquitination

Colette B. Rogers, Wendy Leung, Ryan M. Baxley, Rachel E. Kram, Liangjun Wang, Joseph P. Buytendorp, Khoi Le, David A. Largaespada, Eric A. Hendrickson, Anja‐Katrin Bielinsky

The paper shows that RAD18 inactivation in HCT116 cells increases recombination and reduces TLS activity, linked to PCNA K164 ubiquitination, but not SUMOylation.

bioRxiv · Sep 3, 2024 · PreprintMolecular Biology

A PCNA-K164R mutation impinges on origin activation and mitotic DNA synthesis

Wendy Leung, Ryan M. Baxley, Emma L. Traband, Ya‐Chu Chang, Colette B. Rogers, Liangjun Wang, Wesley Durrett, Kendall Bromley, Lidia Fiedorowicz, Tanay Thakar, Anika Tella, Alexandra Sobeck, Eric A. Hendrickson, George‐Lucian Moldovan, Naoko Shima, Anja‐Katrin Bielinsky

This study shows that PCNA-K164 ubiquitination is essential for DNA gap filling during S/G2 phases and regulates mitotic DNA synthesis by influencing FANCD2 and MCM2-7 loading.

Cell Reports · Dec 1, 2023Peer-reviewedMolecular Biology

Bi-allelic MCM10 mutations cause telomere shortening with immune dysfunction and cardiomyopathy

Ryan M. Baxley, Wendy Leung, Megan Schmit, Jacob P. Matson, Lulu Yin, Marissa K. Oram, Liangjun Wang, John Taylor, Jack Hedberg, Colette B. Rogers, Adam J. Harvey, Debashree Basu, Jenny C. Taylor, Alistair T. Pagnamenta, Helene Marie-Pierre Dreau, , Anja‐Katrin Bielinsky

This study identifies bi-allelic MCM10 mutations causing telomere shortening, immune dysfunction, and cardiomyopathy by impairing DNA replication and telomerase activity.

Nature Communications · Mar 12, 2021Peer-reviewedMolecular Biology

PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation by regulating Okazaki fragment maturation and chromatin assembly

Tanay Thakar, Wendy Leung, Claudia M. Nicolae, Kristen E. Clements, Binghui Shen, Anja‐Katrin Bielinsky, George‐Lucian Moldovan

This study shows that PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation by ensuring efficient Okazaki fragment maturation and chromatin assembly, enhancing resistance to PARP-inhibitors in BRCA-deficient cells.

Nature Communications · May 1, 2020Peer-reviewedMolecular Biology