George‐Lucian Moldovan

This study shows that IGF2BP family proteins suppress RNA-sensing pathways by binding TNFAIP3 mRNA, reducing innate immune signaling in AML cells.

This study identifies POGZ as a novel component of PRC1.6, showing it represses BMP signaling during neuronal differentiation and links to ASD.

The paper identifies the HELQ-RAD52 axis as a regulator of cisplatin-induced ssDNA gap processing through CRISPR screens in human cells.

This study shows that PCNA-K164 ubiquitination is essential for DNA gap filling during S/G2 phases and regulates mitotic DNA synthesis by influencing FANCD2 and MCM2-7 loading.

This study identifies lagging strand ssDNA gaps as drivers of fork degradation in BRCA-deficient cells by inhibiting PCNA unloading and CAF-1-dependent nucleosome assembly.

This study identifies genetic regulators of PARP inhibitor response using CRISPR screens, revealing TIP60 as a key factor that reverses PARPi sensitivity in BRCA2-deficient cells.

This study shows that PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation by ensuring efficient Okazaki fragment maturation and chromatin assembly, enhancing resistance to PARP-inhibitors in BRCA-deficient cells.

This study identifies Wnt signaling activation as a mechanism of PARP inhibitor resistance in HGSOC and shows that combining PARPi with Wnt inhibitors reduces tumor burden.