Anja‐Katrin Bielinsky

This study investigates HMGB1's role in keratinocyte inflammation in RDEB, finding increased HMGB1 expression in wounds and partial suppression of inflammation by pharmacological inhibition.

This study identifies ASCC3 as a helicase that unwinds DNA at stalled replication forks, promoting fork reversal and preventing genomic instability during replication stress.

The paper shows that RAD18 inactivation in HCT116 cells increases recombination and reduces TLS activity, linked to PCNA K164 ubiquitination, but not SUMOylation.

The paper presents a scalable CRISPR-Cas9 platform for chemical-genetic screens of DNA damage-inducing compounds, identifying enriched modes-of-action and revealing late ICL repair pathway responses.

This study shows that PCNA-K164 ubiquitination is essential for DNA gap filling during S/G2 phases and regulates mitotic DNA synthesis by influencing FANCD2 and MCM2-7 loading.

This study shows that elevated Msh2-Msh3 levels interfere with DNA replication and long-patch base excision repair in vivo, contributing to genomic instability.

This study identifies bi-allelic MCM10 mutations causing telomere shortening, immune dysfunction, and cardiomyopathy by impairing DNA replication and telomerase activity.

This study shows that PCNA ubiquitination protects stalled replication forks from DNA2-mediated degradation by ensuring efficient Okazaki fragment maturation and chromatin assembly, enhancing resistance to PARP-inhibitors in BRCA-deficient cells.