Ya‐Chu Chang

This study investigates HMGB1's role in keratinocyte inflammation in RDEB, finding increased HMGB1 expression in wounds and partial suppression of inflammation by pharmacological inhibition.

This paper develops a yeast-based high-throughput screening platform to identify small molecules modulating pre-mRNA splicing, identifying 4 compounds and showing one affects splicing in cancer cells with a splicing factor mutation.

The paper presents a scalable CRISPR-Cas9 platform for chemical-genetic screens of DNA damage-inducing compounds, identifying enriched modes-of-action and revealing late ICL repair pathway responses.

This study shows that PCNA-K164 ubiquitination is essential for DNA gap filling during S/G2 phases and regulates mitotic DNA synthesis by influencing FANCD2 and MCM2-7 loading.