Multicomponent Thiolactone-Based Ionizable Lipid Screening Platform for an Efficient and Tunable mRNA Delivery to the Lungs
Álvaro Peña, Juan Heredero, Beatriz Blandín, Elena Mata, Diego de Miguel, Alfonso Toro-Córdova, Teresa Alejo, Diego Casabona, Alexandre López, Ana Gallego-Lleyda, Esther Pérez‐Herrán, Juan Martínez-Oliván, Javier Giménez-Warren
This paper develops a lipid screening platform to identify efficient and tunable ionizable lipids for mRNA delivery to the lungs, resulting in a lipid that enhances protein expression and shows selective lung targeting.
Communications Chemistry · Apr 15, 2025Peer-reviewedBiochemistry