Juan Martínez-Oliván

This study enhances mRNA translation efficiency by engineering Kozak repeats in the 5'-UTR, showing improved expression in both cell culture and mice.

This paper develops a complete approach for circRNA therapeutics, including purification, lipid nanoparticle formulation with novel ionizable lipids, and lyophilization to improve stability and delivery.

This paper develops a lipid screening platform to identify efficient and tunable ionizable lipids for mRNA delivery to the lungs, resulting in a lipid that enhances protein expression and shows selective lung targeting.

CertPrime improves oligonucleotide design by reducing melting temperature deviations and spurious dimer formation, enhancing gene synthesis efficiency.