IGF1 peptide targets Rett Syndrome astrocytes to degrade IGF binding protein, rescue synaptogenesis and restore mitochondrial function
Prachi Ojha, Velina Kozareva, Alexandria R. Barlowe, Fabian Schulte, Ruby M. Lam, Danielle L. Tomasello, Ernest Fraenkel, Rudolf Jaenisch, Mriganka Sur
The paper shows that an IGF1-derived peptide reduces IGFBP2 in RTT astrocytes, improving synaptogenesis and mitochondrial function in neurons.
bioRxiv · Jul 11, 2026 · PreprintNeuroscience