Author

Prachi Ojha

Massachusetts Institute of TechnologyORCID 0000-0002-5579-7104Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Assay:electronic health records· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Mriganka SuriD· 3 shared Arundhati NatesaniD· 2 shared Gabrielle T DrummondiD· 2 shared Giselle FernandesiD· 2 shared Grayson O. SipeiD· 2 shared Jiho ParkiD· 2 shared Rudolf JaenischiD· 2 shared Yuma OsakoiD· 2 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Mriganka SurORCID

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3 papers

Recent·Most cited

IGF1 peptide targets Rett Syndrome astrocytes to degrade IGF binding protein, rescue synaptogenesis and restore mitochondrial function

Prachi Ojha, Velina Kozareva, Alexandria R. Barlowe, Fabian Schulte, Ruby M. Lam, Danielle L. Tomasello, Ernest Fraenkel, Rudolf Jaenisch, Mriganka Sur

The paper shows that an IGF1-derived peptide reduces IGFBP2 in RTT astrocytes, improving synaptogenesis and mitochondrial function in neurons.

bioRxiv · Jul 11, 2026 · PreprintNeuroscience

Astrocytic modulation of population encoding in mouse visual cortex via GABA transporter 3 revealed by multiplexed CRISPR/Cas9 gene editing

Jiho Park, Grayson O. Sipe, Xin Tang, Prachi Ojha, Giselle Fernandes, Yi Ning Leow, Caroline Zhang, Yuma Osako, Arundhati Natesan, Gabrielle T Drummond, Rudolf Jaenisch, Mriganka Sur

This study uses CRISPR/Cas9 to knockout Gat3 in mouse visual cortex astrocytes, revealing its role in shaping neuronal activity and sensory information encoding.

eLife · Sep 30, 2025Peer-reviewedNeuroscience

Cortical astrocytes extend phasic norepinephrine signals and critically mediate learned behavior

Gabrielle T Drummond, Arundhati Natesan, Marco Celotto, Jiho Park, Jennifer Shih, Prachi Ojha, Yuma Osako, Giselle Fernandes, Kyle R. Jenks, Grayson O. Sipe, Vincent Breton‐Provencher, Tatsuya Osaki, Paul C. Simpson, Stefano Panzeri, Mriganka Sur

The paper shows that cortical astrocytes mediate learned behavior by extending norepinephrine signals through calcium dynamics and ATP release, influencing neuronal encoding of task variables.

bioRxiv · Oct 24, 2024 · PreprintNeuroscience