Author

Ruby M. Lam

Massachusetts Institute of TechnologyORCID 0000-0002-3077-3907Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander Theodore ChesleriD· 2 shared Mriganka SuriD· 2 shared Alexandria R. Barlowe· 1 shared Alize Koolen· 1 shared Ardem PatapoutianiD· 1 shared Arthur BeyderiD· 1 shared Carsten G. BönnemanniD· 1 shared Charlotte Rostock· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersNeuroscience

Alexander Theodore CheslerORCID

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4 papers

Recent·Most cited

IGF1 peptide targets Rett Syndrome astrocytes to degrade IGF binding protein, rescue synaptogenesis and restore mitochondrial function

Prachi Ojha, Velina Kozareva, Alexandria R. Barlowe, Fabian Schulte, Ruby M. Lam, Danielle L. Tomasello, Ernest Fraenkel, Rudolf Jaenisch, Mriganka Sur

The paper shows that an IGF1-derived peptide reduces IGFBP2 in RTT astrocytes, improving synaptogenesis and mitochondrial function in neurons.

bioRxiv · Jul 11, 2026 · PreprintNeuroscience

Persistent Disruptions in Prefrontal Connectivity Despite Behavioral Rescue by Environmental Enrichment in a Mouse Model of Rett Syndrome

Sofie Ährlund‐Richter, Jonathan Harpe, Giselle Fernandes, Ruby M. Lam, Mriganka Sur

This study shows that environmental enrichment improves behavioral deficits but not prefrontal cortex connectivity in a mouse model of Rett Syndrome.

The Journal of Comparative Neurology · Jul 1, 2025Peer-reviewedNeuroscience

PIEZO2 in somatosensory neurons controls gastrointestinal transit

M. Rocio Servin‐Vences, Ruby M. Lam, Alize Koolen, Yu Wang, Dimah N. Saade, Meaghan C. Loud, Halil S. Kacmaz, Suzanne Frausto, Yunxiao Zhang, Arthur Beyder, Kara L. Marshall, Carsten G. Bönnemann, Alexander Theodore Chesler, Ardem Patapoutian

The paper shows that PIEZO2 in dorsal root ganglia neurons regulates gut motility by sensing mechanical stretch, affecting gastrointestinal transit.

Cell · Aug 1, 2023Peer-reviewedNeuroscience

HESC-derived sensory neurons reveal an unexpected role for PIEZO2 in nociceptor mechanotransduction

Katrin Schrenk-Siemens, Jörg Pohle, Charlotte Rostock, Muad Y Abd El Hay, Ruby M. Lam, Marcin Szczot, Shiying Lu, Alexander Theodore Chesler, Jan Siemens

The paper generates hESC-derived nociceptor-like cells and shows they exhibit mechano-nociceptive characteristics requiring PIEZO2 for mechanotransduction.

bioRxiv · Aug 23, 2019 · PreprintNeuroscience