Mriganka Sur

This study investigates how ipsilateral and binocular visual responses develop in mouse visual cortex during the critical period, finding reciprocal interactions between ipsi inputs and binocular responses.

This study shows that mice and artificial neural networks reuse modular neuronal subspaces to perform complex cognitive tasks.

The paper shows that an IGF1-derived peptide reduces IGFBP2 in RTT astrocytes, improving synaptogenesis and mitochondrial function in neurons.

The paper shows that motivational states modulate attractor dynamics in the medial prefrontal cortex during working memory tasks, revealing how internal states control neural dynamics and cognitive function.

The paper introduces MICs to analyze how modulators reshape interactions between neural populations using a bilinear perturbation framework, showing its effectiveness in simulations and real neural data.

CHARIOT-AAV conjugates diverse vectors to AAVs to enable tissue-specific delivery and expanded cargo capacity for large genes.

This study examines how different MeCP2 mutations affect neuronal activity and network function in Rett syndrome organoids, finding mutation-specific impairments in connectivity and gene expression.

This study investigates vascular impairment in Rett syndrome by analyzing patient-derived endothelial cells and identifies miR126-3p as a mediator of vascular dysfunction.

This study uses CRISPR/Cas9 to knockout Gat3 in mouse visual cortex astrocytes, revealing its role in shaping neuronal activity and sensory information encoding.

This study identifies circHomer1 as a circRNA critical for synaptic development and experience-dependent plasticity in mouse visual cortex through transcriptome analysis and knockdown experiments.

This study shows that environmental enrichment improves behavioral deficits but not prefrontal cortex connectivity in a mouse model of Rett Syndrome.

The paper shows that the LP-ACC pathway in mice is essential for using prior stimulus history to guide decision-making by estimating differences in evidence between trials.

The paper shows that cortical astrocytes mediate learned behavior by extending norepinephrine signals through calcium dynamics and ATP release, influencing neuronal encoding of task variables.

This study analyzes LC neuron firing patterns across species and biological factors, revealing diverse activity patterns and subregions enriched for specific factors and disease models.

This study shows that modifying the optical properties of a mammalian brain can enhance deep imaging without affecting native physiology.

This study shows that distinct PFC subregions modulate VISp activity differently during behavior, with ACA enhancing visual encoding and ORB shaping movement and arousal-related responses.

This study shows that the A53T mutation in α-synuclein increases pro-inflammatory activation and oxidative stress in human microglia, potentially contributing to early-onset Parkinson's disease.

The paper introduces ENS2, a neural network system for spike inference from calcium imaging data, which outperforms existing methods in spike-rate and spike-event prediction with lower computational cost.

This study transplants FXS patient-derived neurons into mice to study their development and finds FMR1-dependent changes in synaptic activity and morphology.

The paper investigates the role of cortico-subthalamic projections in controlling visually-guided locomotion in mice, finding that M2-STN pathway activity is critical for stopping behavior.

This study identifies behavioral strategies in rodent foraging by analyzing switching dynamics and develops a method to infer mixed strategy use during dynamic tasks.

This paper introduces a non-toxic rabies virus system for long-term in vivo imaging of neuronal networks, showing minimal toxicity and normal visual response properties over 10 weeks.

The paper develops a novel foraging task to study action-outcome associations in mice, revealing that striosomal neurons encode reinforcement outcomes more strongly than matrix neurons.

This study shows that astrocytic glutamate uptake via GLT1 is essential for experience-dependent refinement of ipsilateral eye inputs in the visual cortex, with disruptions causing altered binocular matching and plasticity.

The paper introduces a neural network-based method for spike estimation from calcium imaging data, outperforming existing methods in correlation metrics and showing generalization across calcium indicators.

This study identifies distinct roles of prefrontal cortex projections in modulating sensorimotor behavior through separate circuits for motor response coordination and sensory cue processing.

The paper shows maternally-expressed miRNAs repress paternally-driven genes in neurons, suggesting imprinted miRNAs mediate parental genomic conflict.