Identification of a new family of peptidoglycan transpeptidases reveals atypical crosslinking is essential for viability in Clostridioides difficile
Kevin W. Bollinger, Ute Müh, Karl L. Ocius, Alexis J. Apostolos, Marcos M. Pires, Richard F. Helm, David L. Popham, David S. Weiss, Craig D. Ellermeier
This study identifies a new family of LDTs in C. difficile that catalyze 3-3 peptidoglycan crosslinking, essential for viability and distinct from previously known YkuD domain LDTs.
Proceedings of the National Academy of Sciences · Aug 16, 2024Peer-reviewedMicrobiology