Pioneer-factor activity requires stable chromatin occupancy mediated by both sequence-specific binding and disordered protein domains
Meghan M. Freund, F Javier deHaro-Arbona, Sarah Baloul, Ali Torhorst, Charalambos S. Roussos, Abby J. Ruffridge, Andrew Q. Rashoff, Ryen Hazzard, Peter W. Lewis, Sarah J. Bray, Melissa M. Harrison
This study identifies that both sequence-specific DNA binding and disordered protein domains are required for pioneer-factor chromatin occupancy, with mitotic retention relying only on DNA binding.
Science Advances · Jun 19, 2026Peer-reviewedMolecular Biology