Abby J. Ruffridge

Pioneer-factor activity requires stable chromatin occupancy mediated by both sequence-specific binding and disordered protein domains

This study identifies that both sequence-specific DNA binding and disordered protein domains are required for pioneer-factor chromatin occupancy, with mitotic retention relying only on DNA binding.

Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation

This study shows that CBP, a histone acetyltransferase, has both catalytic and non-catalytic roles in zygotic genome activation, independent of its acetylation function.