Prenatal opioid exposure inhibits microglial sculpting of the dopamine system during adolescence
Caroline J. W. Smith, Tania Lintz, Madeline J. Clark, Karen E. Malacon, Alia Abiad, Nicholas J. Constantino, Veronica J. Kim, Young Chan Jo, Yanaira Alonso‐Caraballo, Staci D. Bilbo, Elena H. Chartoff
This study shows that prenatal opioid exposure reduces microglial pruning of dopamine D1 receptors in male rats, leading to increased D1R density and impaired extinction of oxycodone-conditioned place preference.
Neuropsychopharmacology · Jul 14, 2022Peer-reviewedNeuroscience