Karen E. Malacon

This study shows that juvenile influenza infection in mice impairs myelin development and leads to lasting cognitive and behavioral issues, which can be mitigated by inhibiting the chemokine receptor CCR3.

This study investigates how microglial synaptic engulfment is dysregulated in diffuse midline glioma, leading to imbalanced excitatory-inhibitory synapse ratios and increased neuronal hyperexcitability.

This study identifies the NLGN3-CSPG4-PIEZO1 axis as a regulator of glial precursor cell state and glioma proliferation through mechanosensitive signaling.

This study shows that CAR T cell therapy in mice causes cognitive impairment through CNS immune dysregulation, microglial reactivity, and disrupted oligodendroglial homeostasis.

The paper shows that myelin plasticity in the ventral tegmental area, regulated by dopaminergic activity, is essential for opioid reward and dopamine release dynamics.

The paper shows that prenatal exposure to air pollution and maternal stress in mice causes social deficits in male offspring, which can be prevented by microbiome modulation or dopamine activation.

This study shows that prenatal exposure to environmental toxins and stress impairs microglial function and leads to behavioral issues in male mice.

This study shows that prenatal opioid exposure reduces microglial pruning of dopamine D1 receptors in male rats, leading to increased D1R density and impaired extinction of oxycodone-conditioned place preference.

This study shows how food deprivation alters olfactory behavior in Drosophila larvae by changing neural processing in the antennal lobe through state-dependent circuit dynamics.

This study shows that neonatal immune challenge reduces social behavior in adult female mice and increases somatostatin interneurons in the ACC, independent of microglial inflammation.