Nicholas J. Constantino

This study examines sex differences in relapse vulnerability after oxycodone abstinence by analyzing neural circuit adaptations in the thalamo-accumbal pathway in male and female rats.

This study shows that Kir6.2-KATP channels regulate glycolytic flux, neuronal activity, and sleep-wake transitions by modulating lactate dynamics and metabolic stability.

This study shows that acute hyper- and hypoglycemia disrupt the metabolic cooperation between glucose and lactate in the brain, affecting sleep-wake cycles.

This study shows that prenatal opioid exposure reduces microglial pruning of dopamine D1 receptors in male rats, leading to increased D1R density and impaired extinction of oxycodone-conditioned place preference.

This study shows that Kir6.2-KATP channels are necessary for hyperglycemia-induced increases in amyloid-beta and Alzheimer's pathology by regulating lactate transport and Aβ release.