Discovery of a pyrazolopyridine alkaloid that mitigates neuronal ER stress and age-related decline
Salinee Jantrapirom, Apiwat Sangphukieo, Natsinee U-on, Pattaporn Poonsawas, Wasinee Wongkummool, Ranchana Yeewa, Chansunee Panto, Puttachat Poound, Ester Zito, Alice Marrazza, Luca Lo Piccolo
The paper identifies a pyrazolopyridine alkaloid, S88, that reduces ER stress and age-related decline in neuronal and Drosophila models.
Communications Biology · May 8, 2026Peer-reviewedNeuroscience