Thorsten M. Schlaeger

RNA splicing factor mutations drive myeloid neoplasm oncogenesis through protein complex poisoning

This study identifies how RNA splicing factor mutations drive myeloid neoplasm by disrupting proteomic networks through mis-splicing, validated via single-cell transcriptomics and proteomics.

Flow-Induced Yap/Taz Signaling Balances Endothelial and Hematopoietic Stem Cell Fates

This study shows that hemodynamic forces activate YAP signaling via Piezo1 in hemogenic endothelium, promoting HSC production by regulating metabolic and gene regulatory programs, while TAZ overactivation disrupts this balance.

Efficient Generation of Functional TCRαβ+ Cytotoxic T Cells from hiPSCs via Small-Molecule Modulation

This paper identifies small-molecule modulators that enhance the generation of functional cytotoxic T cells from hiPSCs, increasing CTL production up to 2000-fold.

Bnip3lb-driven mitophagy sustains expansion of the embryonic hematopoietic stem cell pool

This study shows that Bnip3lb-driven mitophagy maintains embryonic HSPC multipotency and expansion by regulating ROS levels, and enhances ex vivo hematopoietic potential of iPSC-derived HSPCs.

Reversing transgene silencing via targeted chromatin editing

This study investigates how DNA methylation and H3K9me3 maintain transgene silencing and shows that targeted DNA demethylation can reverse it in mammalian cells.

Heterochromatin fidelity is a therapeutic vulnerability in lymphoma and other human cancers

The paper identifies KDM4 demethylase inhibition as a therapeutic strategy for lymphoma and other cancers by rewiring heterochromatin and inducing DNA damage.

Design of a Soluble Multivalent Notch Agonist

This paper designs soluble multivalent Notch agonists to activate Notch signaling in vitro, enabling T cell differentiation and immunotherapy development.

Preimplantation Embryos Amplify Stress-Induced Changes in Sperm-Derived miRNA Content to Mediate Transgenerational Epigenetic Inheritance

This study shows that chronic stress in male mice reduces sperm miR-34c levels through astrocyte-derived exosomes, leading to transgenerational anxiety and reduced sociability in offspring.

Synthetic genetic circuits to uncover and enforce the OCT4 trajectories of successful reprogramming of human fibroblasts

The paper identifies OCT4 trajectories critical for reprogramming human fibroblasts to iPSCs and develops a synthetic genetic circuit to enforce these trajectories, improving reprogramming efficiency.

Matrin3 mediates differentiation through stabilizing chromatin accessibility and chromatin loop-domain interactions, and YY1 mediated enhancer-promoter interactions

The paper shows Matrin3 stabilizes chromatin accessibility and loop-domain interactions, and facilitates YY1-mediated enhancer-promoter interactions during differentiation.

Extracellular vesicles improve GABAergic transmission in Huntington's disease iPSC-derived neurons

The paper shows that extracellular vesicles from healthy cells can reverse GABAergic synaptic deficits in Huntington's disease neurons by modulating miRNA content.

Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells

This paper reports the derivation of airway basal stem cells from human iPSCs, demonstrating their ability to self-renew and differentiate into airway epithelial cell types, and model lung diseases.

Integrative Genomic Analysis and Functional Studies Reveal GP5, GRN, MPO and MCAM as Causal Protein Biomarkers for Platelet Traits

The paper identifies four proteins causally linked to platelet traits using genomic, epidemiological, and experimental data.