Single-molecule reaction chambers reveal intramolecular protein kinase activation
Eva Krötenheerdt, Alina Ehrl, Christian Stelmach, Francesco Reina, Lucas Piëch, Florian Praetorius, Jonas Ries, Bojan Žagrović, Thomas A. Leonard
The paper demonstrates that protein kinases can undergo intramolecular autophosphorylation using single-molecule reaction chambers, challenging the conventional view of intermolecular activation.
bioRxiv · Oct 9, 2026 · PreprintBiochemistry