Florian Praetorius

Aminoacylated tRNA tails trigger auxiliary bacterial immunity

The paper shows that cleaved aminoacylated tRNA tails trigger auxiliary bacterial immunity by activating Adt1, leading to mRNA cleavage and cellular dormancy.

Single-molecule reaction chambers reveal intramolecular protein kinase activation

The paper demonstrates that protein kinases can undergo intramolecular autophosphorylation using single-molecule reaction chambers, challenging the conventional view of intermolecular activation.

Design of facilitated dissociation enables control over cytokine signaling duration

The paper designs proteins with controlled dissociation rates by introducing strained excited states, enabling rapid cytokine receptor dissociation.

Reconfigurable asymmetric protein assemblies through implicit negative design

This paper designs reconfigurable asymmetric protein assemblies using implicit negative design principles, enabling stable subunit exchange and diverse complex formations.